KMID : 0387420020130010079
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Korean Society of Oriental Neuropsychiatry 2002 Volume.13 No. 1 p.79 ~ p.115
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The Effects of Crataegus prinnatiflora BGE. var. major N.E. BR(CPVM) Extract on the the Alzheimer¡¯s Disease Model Induced by CT105
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Jung In-Chul
Lee Sang-Ryong Chae Jong-Gu
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Abstract
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This research investigates the effect of the Crataegus pinnatifida BGE. var. major N.E. BR(CPVM) on Alzheimer¡¯s disease. Specifically, the effects of the DYHT extract on (1) $IL-1{\beta}$, IL-6, amyloid precursor proteins(APP), acetylcholinesterase(AChE), and glial fibrillary acidic protein(GFAP) mRNA of PC-12 cells treated with CTI05; (2) the AChE activity and the APP production of PC-12 cell treated with CT105; (3) the behavior; and (4) expression of $IL-1{\beta}$, $TNF-{\alpha}$, reactive oxygen species(ROS), nitrite oxide(NO); and (5) the infarction area of the hippocampus, and brain tissue injury in Alzheimer¡¯s diseased mice induced with CT105 were investigated. The results are as follow. 1. The CPVM extract suppressed the expression of $IL-1{\beta}$, IL-6, APP, AChE, and GFAP mRNA in PC-12 cells treated with CT105. 2. The CPVM extract suppressed the AChE activity and the production of APP significantly in PC-12 cells treated with CT105. 3. The CPVM extract group showed a significant inhibitory effect on the memory deficit for the mice with Alzheimer¡¯s disease induced by CT105 in the Morris water maze experiment. 4. The CPVM extract suppressed the over-expression of $IL-1{\beta}$, $TNF-{\alpha}$, ROS and NO in the mice with Alzheimer¡¯s disease induced by CT105. 5. The CPVM extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer¡¯s disease induced by CT105. These results suggest that the CPVM extract may be effective for the prevention and treatment of Alzheimer¡¯s disease.
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KEYWORD
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CT105, Crataegus pinnatifida BGE. var. major N.E. BR(CPVM , ߣÞÛë¿), Alzheimer¡¯s disease, amyloid precursor proteins(APP), cytokine, acetylcholinesterase(AChE)
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